MorphRx.aiParminder Mankoo, Ph.D.
Computational chemist and bioinformatics leader with 15+ years bridging multi-omic science, AI, and cloud-scale product delivery across biotech startups and global pharma organizations.
Architected AI-native translational pipelines from target nomination through IND/FIH submissions across modalities including LNPs, antibodies, and small molecules.
Built enterprise AI/ML platforms that generated 1M+ novel lipid nanoparticle structures and unified generative chemistry with RNA/LNP modeling.
Led bioinformatics, multi-omics integration, and biomarker discovery for immuno-oncology, cell therapy, and vaccine programs across biotech and big pharma.
Scaled compliant, cloud-native data ecosystems (AWS, GCP) that power sequencing, visualization, and CRO/SaaS collaboration workflows.
15+
years leading translational science
1M+
AI-generated LNP structures
$10M+
revenue unlocked (TrexBio, Abiosciences)
12
patents & major presentations
Experience
A career spanning startups, big pharma, and world-class research hospitals—each chapter advancing AI, multi-omics, and translational medicine to move programs from concept to clinic.
Synamics Therapeutics
Apr 2025 – Aug 2025
Chief Technology Officer
Directed Dynaptive, an AI-first discovery platform blending generative chemistry, resistance prediction, and translational workflows; led fundraising storytelling and platform strategy end-to-end.
Liberate Bio
Jan 2023 – Jan 2025
Vice President of Computational Sciences
Unified generative AI chemistry, RNA/LNP modeling, and PBPK simulations to discover extra-hepatic delivery vehicles, delivering 1M+ novel structures and AWS-funded infrastructure.
Clover Biopharmaceuticals
Oct 2021 – Dec 2022
Senior Director, Head of Bioinformatics
Built oncology strategy, antibody design analytics, and COVID vaccine sequencing pipelines, integrating single-cell, spatial, and clinical datasets into executive-ready decision tools.
Abiosciences Inc.
Mar 2020 – Oct 2021
Head of Bioinformatics
Scaled single-cell and spatial pipelines for engineered cell therapies, managing global Ph.D. teams and launching software products like Omnibrowser to commercial partners.
TRexBio
Jan 2019 – Mar 2020
Director of Discovery & Translational Bioinformatics
Generated multimillion-dollar revenue via Treg target discovery, deploying large-scale single-cell analytics, GWAS integration, and AWS-native visualization suites.
Bristol Myers Squibb
May 2016 – Dec 2018
Principal Scientist, Translational Medicine
Led biomarker discovery, clinical readiness, and machine learning programs for IO assets, shaping IND submissions and translational go/no-go decisions.
Sanofi
May 2011 – May 2016
Senior Research Investigator, Translational & Experimental Medicine
Delivered ADC target mining, assay development, and automated RNA-seq infrastructure (RASP) deployed across oncology programs worldwide.
Memorial Sloan Kettering Cancer Center
May 2009 – May 2011
Research Scholar
Advanced multi-omic machine learning models predicting survival and treatment response, co-authoring TCGA landmark studies.
Johns Hopkins Institute of Computational Medicine
Mar 2009 – Apr 2011
Postdoctoral Fellow
Developed mutation-scoring algorithms, protein-structure-informed ML models, and pharmacophore approaches that informed cancer genomics discoveries.
Operating system
Outcome-first
Define measurable translational endpoints early—then design AI, experimental, and regulatory workstreams to hit them.
Co-create boldly
Fold medicinal chemistry, biology, data science, and exec stakeholders into a single product cadence to accelerate trust.
Mentor & multiply
Equip teams with playbooks, infrastructure, and governance that outlast any single engagement.
Education
Ph.D., Computational Chemistry & Biophysics
Boston University
2007
M.Sc. (Hons.), Theoretical & Computational Chemistry
Panjab University, Chandigarh
2001
B.Sc. (Hons.), Chemistry
Panjab University, India
1999